Main characters

Simon (シモン Shimon?)
Voiced by: Tetsuya Kakihara (Japanese), Yuri Lowenthal (English)
Simon is the main protagonist of Gurren Lagann. He is introduced as a fourteen-year-old digger from Giha village who is looked down upon by many of his peers for his timid and weak character. He greatly admires Kamina, one of his few friends in the village, and refers to him as his brother despite them not being related by blood. Simon spends much of the first quarter of the series following after Kamina, but gradually acquires his own fighting spirit and determination over the course of the series, acting on his own more often until his personality mirrors that of Kamina. His discovery of the Core Drill and the Gunmen Lagann are what set the events of the series in motion. Throughout the series, Simon primarily pilots Lagann, which is capable of producing drills from any part of its body when it reacts to Simon's Spiral energy. He uses this ability to combine with Kamina's Gunmen, Gurren, to form Gurren Lagann. He can also take control of other Gunmen using this ability.

Team Dai-Gurren
Kamina (カミナ?)
Voiced by: Katsuyuki Konishi (Japanese), Kyle Hebert (English)
Kamina is a refractory youth from Giha village who dreams of leaving his underground home and going to the surface world, which he saw as a child. His extremely passionate and self-confident personality causes him to act as a foil for the more timid and weak-willed Simon, and serves to instill courage within Simon. His actions greatly influence the entire series, as he forms Team Dai-Gurren and acts as its leader to combat the threat of Lordgenome and the beastmen. Early in the series, Kamina hijacks a Gunmen he names Gurren, which he pilots while combined with Simon's Lagann to form Gurren Lagann.

Yoko Littner (ヨーコ・リットナー Yōko Rittonā?)
Voiced by: Marina Inoue (Japanese), Michelle Ruff (English)
Yoko is a young woman from Littner, a village neighboring Giha, and is introduced as a member of a small resistance against the beastmen. She helps introduce Simon and Kamina to the surface world, and becomes a member of Team Gurren soon after. She falls in love with Kamina early in the series, and thinks little of Simon until he begins showing signs of self-confidence. After Kamina's death, she tries to help Simon cope and forms a sisterly relationship with him. Instead of piloting a Gunmen, she wields a high-powered energy rifle and uses her superb marksmanship and wise council to help her teammates.

Nia Teppelin (ニア・テッペリン Nia Tepperin?)
Voiced by: Yukari Fukui (Japanese), Hynden Walch (episodes 9-16), Bridget Hoffman (episodes 17-27) (English)
Nia is a major character introduced later on in the series. Having lived a sheltered life as the daughter of Lordgenome, the main antagonist of the first half of the series, she is ignorant of the war between the humans and Lordgenome until she is abandoned by her father and discovered by Simon. She is a very polite and naive girl who is curious about the world, and acts as a soothing influence for Simon following his depression caused by Kamina's death. The two fall in love and become engaged at the start of the second half of the series, after which she is discovered to be an agent of the Anti-Spirals. During this time, Nia is taken over by a cold and uncaring personality called "Messenger Nia" and forced to fight Simon against her will until Simon rescues her. Because her existence is tied with that of the Anti-Spirals, however, she fades away with them after they are defeated, but keeps herself alive long enough to marry Simon.